| Abstract | A study was started in 1976 whereby patients with Stage II and operable Stage III MBC were given adjuvant Tamoxifen for 1 year, increasing to 2 years from 1988. All patients had axillary nodal involvement. Primary treatment consisted of a radical mastectomy or simple mastectomy with radiotherapy. The rarity of the disease precluded a randomised trial. Thirty-nine patients are available for analysis at a median follow-up of 49 months. The actuarial survival of the Tamoxifen treated patients is 61% (range 42-80%) at 5 years compared to 44% (range 35-53%) for historical controls (P = 0.006). Disease-free survival was 56% (37-75%) vs 28% (17-33%) at 5 years (P = 0.005). There were no serious side-effects recorded. The conclusion from this, the first reported series on adjuvant Tamoxifen therapy for MBC, is that significant improvement in disease-free survival can be achieved with minimal upset to the patients. Recruitment to the study continues. |
| Authors | G Ribeiro, R Swindell
(Affiliation: Department of Clinical Oncology and Medical Statistics, Christie Hospital, Withington, Manchester, UK.)
|
| Journal | British journal of cancer
(Br J Cancer)
Vol. 65
Issue 2
Pg. 252-4
(Feb 1992)
ISSN: 0007-0920 ENGLAND |
| PMID | 1739625
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
|
| Topics |
- Actuarial Analysis
- Adult
- Aged
- Breast Neoplasms
(drug therapy, mortality)
- Humans
- Male
- Middle Aged
- Survival Analysis
- Tamoxifen
(therapeutic use)
|
