| Abstract | Polyamine metabolic genes are downstream targets of several genes commonly mutated in colon adenomas and cancers. Inhibitors of ornithine decarboxylase, such as difluoromethylornithine (DFMO), and agents that stimulate polyamine acetylation and export, such as non-steroidal anti-inflammatory drugs (NSAIDS), act at least additively to arrest growth in human cell models and suppress intestinal carcinogenesis in mice. These preclinical studies provided the rationale for colon cancer prevention trials in humans. A Phase IIb clinical study comparing the combination of DFMO and the NSAID sulindac versus placebo was conducted. Endpoints were colorectal tissue polyamine and prostaglandin E2 contents and overall toxicity to participants. Participants in the Phase IIb study served as a vanguard for a randomized, placebo-controlled prospective Phase III trial of the combination of DFMO and sulindac with the primary study endpoint the prevention of colon polyps. Seventy percent of participants will have completed the three years of treatment in December 2006. |
| Authors | E W Gerner, F L Meyskens Jr, S Goldschmid, P Lance, D Pelot
(Affiliation: Arizona Cancer Center, Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA. egerner at azcc.arizona.edu)
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| Journal | Amino acids
(Amino Acids)
Vol. 33
Issue 2
Pg. 189-95
(Aug 2007)
ISSN: 1438-2199 Austria |
| PMID | 17396214
(Publication Type: Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article, Research Support, N.I.H., Extramural, Review)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Polyamines
- Eflornithine
- Ornithine Decarboxylase
|
| Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Clinical Trials as Topic
(methods)
- Colonic Neoplasms
(metabolism, prevention & control)
- Colonic Polyps
(prevention & control)
- Eflornithine
(therapeutic use)
- Female
- Genes, APC
(drug effects)
- Genes, ras
(drug effects)
- Humans
- Male
- Middle Aged
- Ornithine Decarboxylase
(antagonists & inhibitors)
- Polyamines
(metabolism)
|
