Abstract | RATIONALE: OBJECTIVES: In primates, PCP induces characteristic behavioral symptoms that can be used to model positive and negative symptoms of schizophrenia. This study investigated the effects of GLY treatment in ten socially housed monkeys receiving chronically infused PCP. METHODS: Ten monkeys received escalating then stable doses of continuously infused PCP through a series of subcutaneously implanted osmotic minipumps. During a segment of the highest PCP dose period, monkeys were concurrently treated with glycine (2 g kg(-1) day(-1) bid p.o.). Behavioral observations were recorded during baseline and treatment periods. RESULTS: Chronic PCP treatment was associated with a progressive decrease in stereotyped pacing and a progressive increase in scanning behavior. Eight of ten animals had one or more episodes of extreme motoric and physiological responses precipitated by stressful events. GLY treatment significantly reversed the effects of PCP on stereotyped pacing but had no effect on scanning. CONCLUSIONS: The results support GLY treatment as beneficial for negative symptoms of schizophrenia. Although further validation is needed, the results also indicate that chronic PCP in primates may be an appropriate model system for development of drugs targeting positive and negative symptoms of schizophrenia.
|
Authors | Gary S Linn, Robert T O'Keeffe, Kenneth Lifshitz, Charles Schroeder, Daniel C Javitt |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 192
Issue 1
Pg. 27-38
(May 2007)
ISSN: 0033-3158 [Print] Germany |
PMID | 17393142
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Glycine Agents
- Hallucinogens
- Phencyclidine
- Glycine
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Cebus
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Female
- Glycine
(pharmacology)
- Glycine Agents
- Hallucinogens
(pharmacology)
- Male
- Motor Activity
(drug effects)
- Phencyclidine
(pharmacology)
- Schizophrenia
(drug therapy)
- Stereotyped Behavior
(drug effects)
- Stress, Psychological
|