| Abstract | The success of anti-cancer therapies largely depends on the ability of the therapeutics to reach their designated cellular and intracellular target sites, while minimizing accumulation and action at non-specific sites. Surface modification of nanoparticulate carriers with poly(ethylene glycol) (PEG)/poly(ethylene oxide) (PEO) has emerged as a strategy to enhance solubility of hydrophobic drugs, prolong circulation time, minimize non-specific uptake, and allow for specific tumor-targeting through the enhanced permeability and retention effect. Furthermore, PEG/PEO modification has emerged as a platform for incorporation of active targeting ligands, thereby providing the drug and gene carriers with specific tumor-targeting properties through a flexible tether. This review focuses on the recent developments surrounding such PEG/PEO-surface modification of polymeric nanocarriers to promote tumor-targeting capabilities, thereby enhancing efficacy of anti-cancer therapeutic strategies. |
| Authors | Lilian E van Vlerken, Tushar K Vyas, Mansoor M Amiji
(Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA.)
|
| Journal | Pharmaceutical research
(Pharm Res)
Vol. 24
Issue 8
Pg. 1405-14
(Aug 2007)
ISSN: 0724-8741 United States |
| PMID | 17393074
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antineoplastic Agents
- Polyethylene Glycols
|
| Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Drug Delivery Systems
(methods)
- Gene Therapy
(methods)
- Humans
- Models, Biological
- Nanoparticles
(chemistry)
- Neoplasms
(drug therapy, therapy)
- Polyethylene Glycols
(chemistry)
|
