Abstract | AIM: METHODS: MAJOR FINDINGS AND CONCLUSIONS: We found different pattern of interleukin-10 production in protected mice compared with unprotected ones. The difference is greatest 24 hours postinfection. The ratios between IL-10 and proinflammatory cytokines confirmed the suppressed proinflammatory response in protected animals, especially 24 hours postinfection. Hence the mortality in unprotected mice begins immediately after we conclude that such cytokine relation and IL-10 production are, at least partially, responsible for the destiny of infected animals and the outcome of infection.
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Authors | Tomislav Rukavina, Brigita Ticac, Vanja Vasiljev |
Journal | Mediators of inflammation
(Mediators Inflamm)
Vol. 2006
Issue 6
Pg. 69431
( 2006)
ISSN: 0962-9351 [Print] United States |
PMID | 17392590
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Interleukin-6
- Lipopolysaccharides
- Tumor Necrosis Factor-alpha
- Interleukin-10
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Topics |
- Animals
- Antibodies, Monoclonal
- Immunity, Active
- Inflammation
(etiology, immunology)
- Interleukin-10
(immunology, metabolism)
- Interleukin-6
(metabolism)
- Kinetics
- Klebsiella Infections
(complications, immunology, mortality)
- Lipopolysaccharides
(immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Tumor Necrosis Factor-alpha
(metabolism)
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