| Abstract | BACKGROUND: Gastroesophageal reflux disease (GERD) influences the symptoms of asthma with acid and oxidative stress. OBJECTIVES: The purpose of this study was to determine the usefulness of measurement of the acid stress marker pH and the oxidative stress marker 8-isoprostane by exhaled breath condensate in proton pump inhibitor (PPI) therapy effect on moderate asthma patients with GERD. METHODS: The pH and the concentration of 8-isoprostane were measured in the exhaled breath condensate of patients with moderate asthma (n = 36) and healthy subjects (n = 26). Two months of PPI therapy (lansoprazole at 30 mg/day) were done in the asthma patients with (n = 13) or without (n = 13) GERD according to a questionnaire for the diagnosis of reflux disease, and exhaled markers were measured. RESULTS: The pH was lower (7.3 +/- 0.3) and the 8-isoprostane level was higher (27.7 +/- 2.3) in the asthma patients than in the healthy control subjects (pH 7.5 +/- 0.2 and 8-isoprostane 6.6 +/- 1.2). Two months of PPI therapy improved the pH (from 7.2 +/- 0.1 to 7.3 +/- 0.1) and the 8-isoprostane concentration (from 32.7 +/- 3.4 to 19.2 +/- 3.4) in the asthma patients with GERD, along with improvement of GERD symptoms. However, these markers did not change in the asthma patients without GERD. CONCLUSIONS: Measurement of the pH and 8-isoprostane level of exhaled breath condensate may be useful to evaluate the influence of GERD on asthma, as well as to determine the timing of intermittent PPI therapy. |
| Authors | Yasuo Shimizu, Kunio Dobashi, Jian Jun Zhao, Tadayoshi Kawata, Akihiro Ono, Noriko Yanagitani, Kyoichi Kaira, Mitsuyoshi Utsugi, Takeshi Hisada, Tamotsu Ishizuka, Masatomo Mori
(Affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan. yasuos at med.gunma-u.ac.jp)
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| Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 74
Issue 5
Pg. 558-64
( 2007)
ISSN: 0025-7931 Switzerland |
| PMID | 17389779
(Publication Type: Journal Article)
|
| Copyright | Copyright 2007 S. Karger AG, Basel. |
| Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Biological Markers
- Proton Pumps
- lansoprazole
- 8-epi-prostaglandin F2alpha
- Dinoprost
|
| Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(pharmacology, therapeutic use)
- Asthma
(drug therapy, epidemiology)
- Biological Markers
(analysis)
- Breath Tests
- Comorbidity
- Dinoprost
(analogs & derivatives, analysis)
- Female
- Gastroesophageal Reflux
(epidemiology)
- Humans
- Hydrogen-Ion Concentration
- Male
- Middle Aged
- Oxidative Stress
- Proton Pumps
(antagonists & inhibitors)
|
