Abstract | BACKGROUND: AIM: METHODS: RESULTS:
E-cadherin, beta-catenin and p120(ctn) were expressed strongly on the cuboidal cell membranes, while beta-catenin was also expressed the cuboid cytoplams in 25 PSH patients. However, in the polygonal cell membranes, the expression levels of these molecules were decreased, and mainly cytoplamic. Specifically, E-cadherin, beta-catenin and p120(ctn) were expressed in both the cytoplasm and on the cell membranes in the intracavitary lining cells of the hemorrhagic regions. The expression phenotype in proliferating type II pneumocytes in the eight pulmonary inflammatory pseudotumors was similar to that in the cuboidal cells in PSH patients. CONCLUSION: The cuboidal cells, resembling inflammatory proliferative type II pneumocytes, display several characteristics of epithelial cells, including normal expression of E-cadherin and catenin. Comparatively, polygonal cells are not as mature as cuboidal cells and lack of expression of E-cadherin and catenin.
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Authors | Shun-Dong Dai, Xiu-Wei Zhang, Feng-Jie Qi, Hong-Tao Xu, En-Hua Wang |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 57
Issue 1
Pg. 54-9
(Jul 2007)
ISSN: 0169-5002 [Print] Ireland |
PMID | 17383052
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Cadherins
- Catenins
- Cell Adhesion Molecules
- Phosphoproteins
- beta Catenin
- Delta Catenin
- CTNND1 protein, human
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Topics |
- Cadherins
(metabolism)
- Catenins
- Cell Adhesion Molecules
(metabolism)
- Humans
- Immunohistochemistry
- Phosphoproteins
(metabolism)
- Plasma Cell Granuloma, Pulmonary
(metabolism, pathology)
- Pulmonary Sclerosing Hemangioma
(metabolism, pathology)
- beta Catenin
(metabolism)
- Delta Catenin
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