Abstract | BACKGROUND: Cutaneous mast cell disorders are uncommon, but a subset, especially mastocytoma and mast cell leukemia, can histologically mimic myeloid leukemia cutis. Our objective was to employ a panel of cytochemical and immunohistochemical markers to determine which ones would be most useful in separating these two entities. METHODS: We stained 17 cases of cutaneous mast cell disease and 20 cases of myeloid leukemia cutis with Giemsa, toluidine blue, or pinacyanol erythrosinate (PE), as well as with antibodies against mast cell tryptase, microphthalmia transcription factor (MiTF), CD117 (c-kit), myeloperoxidase, CD43, CD25, CD2, and CD68. RESULTS: CONCLUSIONS:
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Authors | Uma N Sundram, Yasodha Natkunam |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 34
Issue 4
Pg. 289-95
(Apr 2007)
ISSN: 0303-6987 [Print] United States |
PMID | 17381798
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD2 Antigens
- CD68 antigen, human
- Interleukin-2 Receptor alpha Subunit
- Leukosialin
- Microphthalmia-Associated Transcription Factor
- Proto-Oncogene Proteins c-kit
- Tryptases
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Topics |
- Antigens, CD
(metabolism)
- Antigens, Differentiation, Myelomonocytic
(metabolism)
- CD2 Antigens
(metabolism)
- Diagnosis, Differential
- Humans
- Immunohistochemistry
- Interleukin-2 Receptor alpha Subunit
(metabolism)
- Leukemia, Myeloid
(diagnosis, metabolism)
- Leukosialin
(metabolism)
- Mast Cells
(metabolism, pathology)
- Mastocytosis, Cutaneous
(diagnosis, metabolism)
- Microphthalmia-Associated Transcription Factor
(metabolism)
- Proto-Oncogene Proteins c-kit
(metabolism)
- Tryptases
(metabolism)
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