Clinical utility and applicability of smoothness index, normalized smoothness index and individualized RDH index during treatment of essential hypertension.

Abstract	The purpose of this study was to assess the clinical utility of the smoothness index (SI) and normalized SI (SIn), measures of duration and homogeneity of blood pressure (BP) reduction, during an observation period without antihypertensive therapy followed by a treatment period using dihydropyridines (DHP) in 54 newly diagnosed and previously untreated subjects (age 46.9 +/- 9.1 years) with essential hypertension. In addition, we aimed to describe the reduction-duration-homogeneity (RDH) index for statistical assessment of the BP reduction in the individual patient. Twenty-four-hour BP was lowered during treatment (139.2 +/- 13.9/ 91.0 +/- 7.6 mmHg vs 130.9 +/- 11.3/85.2 +/- 5.2 mmHg, p < 0.001/p = 0.001). SI showed great interindividual variation, and increased from zero to 0.9 +/- 0.8 (systolic BP) and 0.8 +/- 0.7 (diastolic BP) after treatment (p < 0.001 for both), similar results were obtained for SI(n). The RDH index revealed BP reduction in agreement with the change in individual 24-h, daytime and night-time BP. Although SI and SI(n) may add important information regarding the homogeneity of the antihypertensive effect in a group of patients, and the RDH index for the individual patient, conclusions regarding antihypertensive efficacy can be obtained from assessment of the 24-h, daytime and night-time BP changes and ambulatory BP profiles. Based on our findings, we do not recommend the use of SI or RDH index in the clinical practice.
Authors	Aud-E Stenehjem, Ingrid Os
Journal	Blood pressure (Blood Press) Vol. 15 Issue 5 Pg. 281-90 ( 2006) ISSN: 0803-7051 [Print] England
PMID	17380846 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antihypertensive Agents Dihydropyridines
Topics	Adult Antihypertensive Agents (therapeutic use) Blood Pressure (drug effects) Blood Pressure Monitoring, Ambulatory Diastole Dihydropyridines (therapeutic use) Female Humans Hypertension (drug therapy) Male Middle Aged Models, Statistical Systole

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!