| Abstract | Some compounds of Cephalostatin family have shown anti-cancer activity against human cancer cell line and active intensity has close with the stereochemistry of the substituted group, for example, beta-OH at C-12 in compound 2 showed less promising results and the mixture 3 (alpha + beta) showed a large enhancement of the activity compared to the compound 2. So, the work was concentrated on the synthesis diastereomers 10 and 11 were obtained in a pure form. |
| Authors | M Nawasreh
(Affiliation: Basic Sciences Department, Faculty of Engineering Technology, Al-Balqa University, Marka, Amman, Jordan. mnawasra at just.edu.jo)
|
| Journal | Natural product research
(Nat Prod Res)
Vol. 21
Issue 2
Pg. 91-9
(Feb 2007)
ISSN: 1478-6419 England |
| PMID | 17380598
(Publication Type: Journal Article)
|
| Chemical References |
- Phenazines
- Pyrazines
- Spiro Compounds
- Steroids
- cephalostatin I
|
| Topics |
- Models, Chemical
- Molecular Structure
- Phenazines
(chemistry)
- Pyrazines
(chemical synthesis, chemistry)
- Spiro Compounds
(chemistry)
- Stereoisomerism
- Steroids
(chemical synthesis, chemistry)
|
