| Abstract | AIMS: To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant. METHODS: Four women taking dexamphetamine, and their infants were studied. RESULTS: The median maternal dexamphetamine dose was 18 mg day(-1) (range 15-45 mg day(-1)). Median (interquartile range) descriptors were 3.3 (2.2-4.8) for milk/plasma ratio, 21 microg kg(-1) day(-1) (11-39) for absolute infant dose and 5.7% (4-10.6%) for relative infant dose. No adverse effects were seen. In three infants tested, dexamphetamine in plasma was undetected in one (limit of detection 1 microg l(-1)) and present at 18 microg l(-1) and 2 microg l(-1) in the other two. CONCLUSION: Dexamphetamine readily transfers into milk. The relative infant dose was <10% and within a range that is generally accepted as being 'safe' in the short term. |
| Authors | Kenneth F Ilett, L Peter Hackett, Judith H Kristensen, Rolland Kohan
(Affiliation: Pharmacology Unit M510, School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Hwy, Crawley, 6009 Australia. ken.ilett at uwa.edu.au)
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| Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 63
Issue 3
Pg. 371-5
(Mar 2007)
ISSN: 0306-5251 England |
| PMID | 17380592
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
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| Topics |
- Adult
- Attention Deficit Disorder with Hyperactivity
(drug therapy)
- Breast Feeding
- Dextroamphetamine
(adverse effects)
- Female
- Humans
- Infant
- Infant, Newborn
- Milk, Human
(chemistry)
- Pregnancy
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