Abstract | OBJECTIVE: METHODS: By using immunohistochemistry staining and western blot assay, the expression of RUNX3 protein in 66 cases of gastric cancer with various clinicopathologic characteristics were detected, and the effects of RUNX3 protein expression on the outcome of patients undergone surgical resection were evaluated. RESULTS: (1) The expression rate of RUNX3 protein in gastric cancer lesions was 60.6% (40/66), and RUNX3 protein was mainly expressed in the cytoplasm of cancer cells. RUNX3 protein expression in tumor tissues was significantly higher than that in non- tumor tissues. (2) RUNX3 protein expression was correlated with tumor differentiation (P=0.025) and Lauren's classification (P=0.034), but had no relationship with the TNM stage (P=0.085). (3) In sharp contrast, the median survival time of patients who had tumors with negative and positive RUNX3 protein expression were 2478 and 2187 days respectively (P=0.016). CONCLUSIONS:
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Authors | Bei-wen Wu, Jun Zhang, Xu-feng Fei, Zheng-gang Zhu, Wei-xin Cao |
Journal | Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
(Zhonghua Wei Chang Wai Ke Za Zhi)
Vol. 10
Issue 2
Pg. 165-8
(Mar 2007)
ISSN: 1671-0274 [Print] China |
PMID | 17380460
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Core Binding Factor Alpha 3 Subunit
- Runx3 protein, human
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Topics |
- Aged
- Cell Differentiation
- Core Binding Factor Alpha 3 Subunit
(genetics, metabolism)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Stomach Neoplasms
(genetics, pathology)
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