Abstract |
Nitrones 4-7, structurally related to PBN (1), were prepared by reaction of the corresponding aromatic aldehydes with N-tert-butyl hydroxylamine. The protective effects of these nitrones against microvascular damages in ischemia/reperfusion in the 'hamster cheek pouch' assay were studied and 1, as well as 4a, 4b, and 7 (derived from piperonal, O-benzyl vanillin, and furfural, respectively), showed to be more active than shark cartilage or alpha-tocopherol. No correlation was found between the protective effect of these nitrones and their logP (partition coefficient) or their capacity to trap (*) OH and (*)CH(3) radicals.
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Authors | Sothea Kim, Guilherme V M de A Vilela, Jalloul Bouajila, Ayres G Dias, Fatima Z G A Cyrino, Eliete Bouskela, Paulo R R Costa, Françoise Nepveu |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 15
Issue 10
Pg. 3572-8
(May 15 2007)
ISSN: 0968-0896 [Print] England |
PMID | 17379527
(Publication Type: Journal Article)
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Chemical References |
- Cyclic N-Oxides
- Fluorescent Dyes
- Indicators and Reagents
- phenyl-N-tert-butylnitrone
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Topics |
- Animals
- Capillaries
(drug effects, pathology)
- Chromatography, High Pressure Liquid
- Cricetinae
- Cyclic N-Oxides
(chemical synthesis, pharmacology)
- Electron Spin Resonance Spectroscopy
- Fluorescent Dyes
- Indicators and Reagents
- Male
- Mesocricetus
- Mouth Mucosa
(blood supply, pathology)
- Regional Blood Flow
(drug effects)
- Reperfusion Injury
(pathology, prevention & control)
- Spectrophotometry, Ultraviolet
- Structure-Activity Relationship
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