| Abstract | PURPOSE: To investigate the correlation of estrogen receptor (ER) gene polymorphism to dry eye syndrome in postmenopausal women. METHODS: Xba I and Pvu II polymorphism of ER gene were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 65 patients with dry eye syndrome and 73 with controls in postmenopausal women. RESULTS: There was a significant difference of Pvu II polymorphism of ER gene between the patients of dry eye syndrome and controls in postmenopausal women (P < 0.05), but no significant difference was found in Xba I polymorphism of ER gene (P > 0.05). CONCLUSION: There is a significant correlation of Pvu II polymorphism of ER gene with dry eye syndrome in postmenopausal women. It is indicated that the difference in ER genotypes might influence the development of dry eye syndrome. |
| Authors | Yanling He, Xiaoxin Li, Yongzhen Bao, Jianmin Sun, Jinrong Liu
(Affiliation: Department of Ophthalmology, People's Hospital, Beijing University, Beijing 100044 China. heyanling2002 at sohu.com)
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| Journal | Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu
(Yan Ke Xue Bao)
Vol. 22
Issue 4
Pg. 233-6
(Dec 2006)
ISSN: 1000-4432 China |
| PMID | 17378156
(Publication Type: English Abstract, Journal Article)
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