HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Estimation of ultrasonographic markers of chromosomal abnormalities in verification of second trimester maternal serum biochemistry].

AbstractUNLABELLED:
In the case of positive triple test results the presence or absence of sonographic markers is associated not only with fetal abnormalities, but also with a variety of adverse outcomes of pregnancy.
OBJECTIVE:
Evaluation of sonographic markers of chromosomal abnormalities in verification of positive results of triple tests.
MATERIAL AND METHODS:
In consecutive series of 780 pregnant women we performed triple tests at 14-19 weeks. We reviewed the presence or absence of sonographic markers for fetal abnormalities including nuchal thickening (NT), nasal bones (NB), extermities (HL, FL), umbilical cord diameter (UCD), bowel echogenity (BE), renal pyelectasis (DPR) and chorioid plexus cyst (CPC).
RESULTS:
There were 47 (6.02%) positive results of triple tests including 36 (4.6%) cases with false positive result. In the group of affected fetuses we observed at least two sonographic markers. In the group with false-positive results 15 (41.6%) fetuses had adverse pregnancy outcome with only one ultrasound marker.
CONCLUSION:
Positive result of the triple test and the presence of two or more markers of fetal abnormalities increase the risk of fetal abnormalities, whereas absence or presence of only one marker and normal karyotype should classify pregnancy to high risk of adverse perinatal outcome.
AuthorsElzbieta Baś-Budecka, Piotr Sieroszewski, Małgorzata Perenc
JournalGinekologia polska (Ginekol Pol) Vol. 77 Issue 11 Pg. 869-75 (Nov 2006) ISSN: 0017-0011 [Print] Poland
Vernacular TitleOcena markerów ultrasonograficznych wad płodu w weryfikacji dodatnich wyników testu potrójnego.
PMID17378127 (Publication Type: Journal Article)
Topics
  • Abnormalities, Multiple (blood, diagnostic imaging, genetics)
  • Adult
  • Aneuploidy
  • False Negative Reactions
  • False Positive Reactions
  • Female
  • Fetal Diseases (blood, diagnostic imaging, genetics)
  • Genetic Testing (methods)
  • Humans
  • Infant, Newborn
  • Nasal Bone (abnormalities, diagnostic imaging)
  • Neck (abnormalities, diagnostic imaging)
  • Poland
  • Pregnancy
  • Pregnancy Trimester, Second (blood)
  • Prenatal Diagnosis (methods)
  • Sensitivity and Specificity
  • Ultrasonography, Prenatal
  • Umbilical Cord (abnormalities, diagnostic imaging)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: