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Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: a possible association with oral midodrine treatment.

Abstract
We describe a 51-year-old man with a 3-year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause-and-effect relationship cannot be confirmed.
AuthorsJoong-Seok Kim, Kwang-Soo Lee, Sung-Chul Lim, Jae-Young Ahn, In-Uk Song, Yeong-In Kim, Bum-Soo Kim, Hee-Tae Kim
JournalMovement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 22 Issue 7 Pg. 1043-6 (May 15 2007) ISSN: 0885-3185 [Print] United States
PMID17377920 (Publication Type: Case Reports, Journal Article)
Copyright(c) 2007 Movement Disorder Society.
Chemical References
  • Adrenergic alpha-Agonists
  • Midodrine
Topics
  • Adrenergic alpha-Agonists (therapeutic use)
  • Brain (drug effects, pathology)
  • Dementia, Vascular (complications, drug therapy, pathology)
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Midodrine (therapeutic use)
  • Multiple System Atrophy (complications, drug therapy)

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