Abstract | BACKGROUND: METHODS:
Fascin expression was immunohistochemically detected using monoclonal antibody against fascin in 86 paraffin embedded tissues, including 10 cases of sinonasal mucosa with chronic inflammation, 10 of EP, 45 of IP with dysplasia (45 cases were divided into three groups: IP with mild dysplasia, IP with moderate dysplasia, and IP with severe dysplasia, 15 cases each), and 21 of cancerated IP. RESULTS: The level of fascin expression was significantly higher in the neoplastic tissue than that in control group. Fascin expression increased gradually with the progression from sinonasal epithelium with chronic inflammation, IP with mild dysplasia, IP with moderate dysplasia, IP with severe dysplasia, to cancerated IP, and significant difference of fascin expression was observed between any two groups of the five. CONCLUSION: Precancerous lesions of IP exhibit elevated levels of fascin that may be associated with carcinogenesis of IP. Fascin may play a role in the formation of IP and EP.
|
Authors | An-liu Wang, Hong-gang Liu, Yong Zhang |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 120
Issue 5
Pg. 375-9
(Mar 05 2007)
ISSN: 0366-6999 [Print] China |
PMID | 17376306
(Publication Type: Journal Article)
|
Chemical References |
- Carrier Proteins
- Microfilament Proteins
- fascin
|
Topics |
- Adult
- Aged
- Carrier Proteins
(analysis)
- Cell Transformation, Neoplastic
(pathology)
- Female
- Humans
- Immunohistochemistry
- Male
- Microfilament Proteins
(analysis)
- Middle Aged
- Nasal Mucosa
(chemistry)
- Nose Neoplasms
(chemistry, pathology)
- Papilloma, Inverted
(chemistry, pathology)
- Precancerous Conditions
(chemistry)
|