Abstract | BACKGROUND: OBJECTIVE: MATERIAL AND METHOD: The present study was conducted from 1999 to 2004 in the neonatal intensive care unit (NICU) at Queen Sirikit National Institute of Child Health. Patients were selected from all infants > or = 34 weeks gestational age who required high frequency oscillatory ventilation (SLE 2000 HFO, SLE, UK) or conventional mechanical ventilation for hypoxemic respiratory failure caused by PPHN. Diagnosis was confirmed by 2-D echocardiogram visualization with right to left shunt through the foramen ovale or patent ductus arteriosus. Inhaled nitric oxide was given as standard therapy in patients who had two oxygenation indices > or = 20 at least 30 minutes apart after being on a mechanical ventilator. RESULTS: Fifty-five cases were enrolled and male to female ratio was 22.2 tol. The survival rate was 76.4 percent. Inhaled nitric oxide significantly improved oxygenation index, arterial alveolar oxygen tension ratio (a/A O2), and alveolar arterial oxygen gradient in survivors at one hour after treatment. The earliest improvement in oxygen saturation was within ten minutes. Meconium aspiration syndrome was the most common underlying cause of PPHN. No acute complication was found during nitric oxide administration. Chronic lung diseases, delayed development and severe hearing loss in long-term follow up were found in 10, 5, and 2 cases, respectively. CONCLUSION:
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Authors | Uraiwan Chotigeat, Meera Khorana, Wiboon Kanjanapattanakul |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 90
Issue 2
Pg. 266-71
(Feb 2007)
ISSN: 0125-2208 [Print] Thailand |
PMID | 17375630
(Publication Type: Journal Article)
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Chemical References |
- Bronchodilator Agents
- Nitric Oxide
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Topics |
- Administration, Inhalation
- Bronchodilator Agents
(administration & dosage, therapeutic use)
- Female
- Humans
- Hypertension, Pulmonary
(complications, drug therapy)
- Hypoxia
(drug therapy, etiology)
- Infant, Newborn
- Intensive Care, Neonatal
(methods)
- Male
- Nitric Oxide
(administration & dosage, therapeutic use)
- Prospective Studies
- Respiratory Insufficiency
(drug therapy, etiology)
- Treatment Outcome
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