| Abstract | Osteonecrosis of the jaws associated with the use of bisphosphonates (alendronate, pamidronate, risedronate et zoledronate) are described as an avascular necrosis. We have listed 184 cases of bisphosphonates-associated osteonecrosis of the maxillary in the literature. Many mechanisms are discussed in bisphosphonates-associated osteonecrosis: a disturbing bone turnover, an accumulation of bone's microdamage or an antiangiogenic effect. Other risk factors seem however to be involved: cancer, chemotherapy, glucocorticoids, infection and renal insufficiency. |
| Authors | Audrey Gering, Laurent Grange, Céline Villier, Anne Woeller, Michel Mallaret
(Affiliation: Centre Hospitalo Universitaire de Grenoble, Centre de pharmacovigilance, Grenoble, France.)
|
| Journal | Thérapie
(Therapie)
2007 Jan-Feb
Vol. 62
Issue 1
Pg. 49-54
ISSN: 0040-5957 France |
| Vernacular Title | Les ostéonécroses de la mâchoire associées aux biphosphonates: synthèse bibliographique. |
| PMID | 17374348
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
|
| Topics |
- Aged
- Bone Density Conservation Agents
(adverse effects, therapeutic use)
- Bone and Bones
(drug effects, metabolism)
- Diphosphonates
(adverse effects, therapeutic use)
- Female
- Humans
- Jaw Diseases
(chemically induced, epidemiology)
- Male
- Osteonecrosis
(chemically induced, epidemiology)
|
