| Abstract | BACKGROUND: Steroid-induced rosacea-like eruption is characterized by facial rosacea-like dermatitis in patients that have been treated with topical steroids for relatively long periods. OBJECTIVE: To evaluate the efficacy and tolerability of 1% pimecrolimus topical cream for steroid-induced rosacea-like eruption. METHODS: In an open-label pilot study, 40 patients were enrolled and instructed to apply 1% pimecrolimus cream twice daily for 6 weeks. Patients were evaluated by a rosacea clinical score, investigator's global assessment, overall erythema severity, and tolerability at weeks 0, 2, and 6. RESULTS: In 35 patients, the rosacea clinical score decreased significantly from 16.0+/-4.3 at baseline to 8.1+/-3.3 at week 2 and 4.2+/-2.5 at week 6 (P<0.0001). Investigator's global assessment was 4.1+/-1.1 (baseline), then decreased to 1.4+/-0.8 (week 2) and 0.5+/-0.6 (week 6) (P<0.0001). By week 6, 48.6% of the patients were clear. Overall erythema severity was 2.4+/-0.7 (baseline), 0.9+/-0.4 (week 2), and 0.3+/-0.4 (week 6) (P<0.0001). Cutaneous adverse events (local burning, stinging, and itching) occurred in 17.5%. CONCLUSION: Pimecrolimus cream might be efficacious, safe, and well tolerated for steroid-induced rosacea-like eruption. The small sample size and open label nature of this study is its limitation. Further double-blind, vehicle-controlled studies are needed. |
| Authors | C-Y Chu
(Affiliation: Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. chiayu.chu at gmail.com)
|
| Journal | Journal of the European Academy of Dermatology and Venereology : JEADV
(J Eur Acad Dermatol Venereol)
Vol. 21
Issue 4
Pg. 484-90
(Apr 2007)
ISSN: 0926-9959 Netherlands |
| PMID | 17373975
(Publication Type: Clinical Trial, Journal Article)
|
| Chemical References |
- Adrenal Cortex Hormones
- Dermatologic Agents
- pimecrolimus
- Tacrolimus
- Calcineurin
|
| Topics |
- Administration, Cutaneous
- Adolescent
- Adrenal Cortex Hormones
(adverse effects)
- Adult
- Aged
- Calcineurin
(antagonists & inhibitors)
- Dermatologic Agents
(administration & dosage, adverse effects, therapeutic use)
- Drug Eruptions
(drug therapy, etiology)
- Erythema
(drug therapy)
- Facial Dermatoses
(chemically induced, drug therapy)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Patient Satisfaction
- Pilot Projects
- Rosacea
(chemically induced, drug therapy)
- Safety
- Tacrolimus
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Telangiectasis
(drug therapy)
- Treatment Outcome
|
