Cytotoxic withanolides from Physalis angulata L.

Abstract

Four new withanolides, physagulins L-O (1-4), were isolated from the MeOH extract of the aerial parts of Physalis angulata L. (Solanaceae), together with seven known withanolides, compounds 5-11. Their structures were determined by spectroscopic techniques, including 1H-, 13C-NMR (DEPT), and 2D-NMR (HMBC, HMQC, 1H,1H-COSY, NOESY) experiments, as well as by HR-MS. All eleven compounds were tested for their antiproliferative activities towards human colorectal-carcinoma (HCT-116) and human non-small-cell lung-cancer (NCI-H460) cells. Compound 5 exhibited the highest anticancer activity against the HCT-116 cell line, with an IC50 value of 1.64+/-0.06 microM. Compound 9 exhibited the highest cytotoxicity towards the NCI-H460 cell line, with an IC50 value of 0.43+/-0.02 microM.

• Authors: Qing-Ping He, Lei Ma, Jie-Ying Luo, Fu-Yuan He, Li-Guang Lou, Li-Hong Hu
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 4 Issue 3 Pg. 443-9 (Mar 2007) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 17372946 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Cytotoxins
• Plant Extracts

Topics

• Antineoplastic Agents (chemistry, isolation & purification)
• Cell Line, Tumor
• Cytotoxins (chemistry, isolation & purification)
• Humans
• Physalis
• Plant Components, Aerial
• Plant Extracts (chemistry, isolation & purification)
• Withania