Abstract |
Homing of hematopoietic stem/progenitor cells (HS/PC) to the bone marrow (BM) microenvironment is the first and essential step in HS/PC engraftment and initiation of the marrow reconstitution during clinical hematopoietic stem cell transplantation (HSCT). How to improve the homing efficiencies and make full use of HS/PC resources, especially umbilical cord blood (UCB), are of great importance in clinical practice. However, the cellular and molecular mechanisms that govern this process are poorly understood. Glycosylphosphatidylinositol- phospholipase D ( GPI-PLD) is an enzyme which can regulate the expression of Glycosylphosphatidylinositol ( GPI)-anchored proteins and modulate their correspondent functions by releasing GPI-anchored proteins from cell membrane. Recent studies suggested that the mechanisms of the malignancy and prognosis of certain tumors were correlated with GPI-PLD. HS/PC homing was similar to tumor invasion and metastasis in some process. Here we proposed the hypothesis that GPI-PLD might also has played a role in the homing of HS/PC by modulating the adhesion and migration of these cells. If GPI-PLD did participate in HS/PC homing, maybe the mechanisms of homing can herefrom be partly elucidated, which would benefit transplantation in clinical practice.
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Authors | Kui Song, Xiaojuan Sun, Jun Wang, Fangping Chen |
Journal | Medical hypotheses
(Med Hypotheses)
Vol. 69
Issue 3
Pg. 660-5
( 2007)
ISSN: 0306-9877 [Print] United States |
PMID | 17368745
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycosylphosphatidylinositols
- Phospholipase D
- Dipeptidyl Peptidase 4
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Topics |
- Animals
- Bone Marrow
(metabolism)
- Cell Transplantation
- Dipeptidyl Peptidase 4
(biosynthesis)
- Glycosylphosphatidylinositols
(metabolism)
- Hematopoietic Stem Cells
(cytology)
- Hematopoietic System
(metabolism)
- Humans
- Models, Biological
- Neoplasm Metastasis
- Neoplasms
(pathology)
- Phospholipase D
(metabolism)
- Prognosis
- Stem Cells
(cytology)
- Surface Properties
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