HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

How Glycosylphosphatidylinositol-phospholipase D acts in homing of hematopoietic stem/progenitor cells?

Abstract
Homing of hematopoietic stem/progenitor cells (HS/PC) to the bone marrow (BM) microenvironment is the first and essential step in HS/PC engraftment and initiation of the marrow reconstitution during clinical hematopoietic stem cell transplantation (HSCT). How to improve the homing efficiencies and make full use of HS/PC resources, especially umbilical cord blood (UCB), are of great importance in clinical practice. However, the cellular and molecular mechanisms that govern this process are poorly understood. Glycosylphosphatidylinositol-phospholipase D (GPI-PLD) is an enzyme which can regulate the expression of Glycosylphosphatidylinositol (GPI)-anchored proteins and modulate their correspondent functions by releasing GPI-anchored proteins from cell membrane. Recent studies suggested that the mechanisms of the malignancy and prognosis of certain tumors were correlated with GPI-PLD. HS/PC homing was similar to tumor invasion and metastasis in some process. Here we proposed the hypothesis that GPI-PLD might also has played a role in the homing of HS/PC by modulating the adhesion and migration of these cells. If GPI-PLD did participate in HS/PC homing, maybe the mechanisms of homing can herefrom be partly elucidated, which would benefit transplantation in clinical practice.
AuthorsKui Song, Xiaojuan Sun, Jun Wang, Fangping Chen
JournalMedical hypotheses (Med Hypotheses) Vol. 69 Issue 3 Pg. 660-5 ( 2007) ISSN: 0306-9877 [Print] United States
PMID17368745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycosylphosphatidylinositols
  • Phospholipase D
  • Dipeptidyl Peptidase 4
Topics
  • Animals
  • Bone Marrow (metabolism)
  • Cell Transplantation
  • Dipeptidyl Peptidase 4 (biosynthesis)
  • Glycosylphosphatidylinositols (metabolism)
  • Hematopoietic Stem Cells (cytology)
  • Hematopoietic System (metabolism)
  • Humans
  • Models, Biological
  • Neoplasm Metastasis
  • Neoplasms (pathology)
  • Phospholipase D (metabolism)
  • Prognosis
  • Stem Cells (cytology)
  • Surface Properties

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: