No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population.

Abstract

The GSK-3 beta gene encodes a protein kinase which is abundant in the brain, and its product is involved in signal transduction cascades of neuronal cell development, energy metabolism and body pattern formation. Previous studies have suggested that GSK-3 beta might act as a potential candidate locus for schizophrenia susceptibility. We genotyped six SNPs within the gene and conducted a case-control study involving 329 schizophrenic patients and 288 healthy subjects in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in the subtype of paranoid schizophrenic patients as well as schizophrenic subjects in general. Our results fail to replicate the association of the GSK-3 beta gene with susceptibility to schizophrenia in the Chinese population.

• Authors: Junwei Meng, Yongyong Shi, Xinzhi Zhao, Jian Zhou, Yonglan Zheng, Ruqi Tang, Gang Ma, Xuming Zhu, Zangdong He, Zhe Wang, Yifeng Xu, Guoyin Feng, Lin He
• Journal: Journal of psychiatric research (J Psychiatr Res) Vol. 42 Issue 5 Pg. 365-70 (Apr 2008) ISSN: 0022-3956 [Print] England
• PMID: 17368486 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycogen Synthase Kinase 3

Topics

• Adult
• Age of Onset
• Asian People (genetics)
• Case-Control Studies
• China (epidemiology)
• Control Groups
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Glycogen Synthase Kinase 3 (genetics)
• Haplotypes
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia (epidemiology, genetics)
• Schizophrenia, Paranoid (epidemiology, genetics)