Cytotoxicity of DP-bioglass paste used for treatment of dentin hypersensitivity.
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| Abstract |
DP-bioglass mixed with 30% phosphoric acid has been suggested to treat dentin hypersensitivity because the material is able to produce homogeneous occlusion of exposed dentinal tubules and is able to provide a sealing depth of up to 60 microm. The purpose of this study was to investigate the relative cytotoxic effect of the DP-bioglass paste, intermediate restorative material (IRM; DeTrey, Dentsply, Germany), and commercial desensitizing agent (Abmindent; Abmin Technologies Ltd, Turku, Finland) on human dental pulp cells by using a transwell insert model and a dentin-disc model. Cell viability was measured by means of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of this study indicated that cell viability for the DP-bioglass paste did not differ significantly from those of the IRM or Abmindent in the transwell insert model. In addition, MTT results of DP-bioglass paste were similar to the control group in the dentin-disc model. The results indicated that DP-bioglass paste was a highly biocompatible material and could potentially serve as an effective material for treatment of dentin hypersensitivity.
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| Authors | Tien-Chun Kuo, Bor-Shiunn Lee, Shu-Han Kang, Feng-Huei Lin, Chun-Pin Lin |
| Journal | Journal of endodontics (J Endod) Vol. 33 Issue 4 Pg. 451-4 (Apr 2007) ISSN: 0099-2399 [Print] United States |
| PMID | 17368337 (Publication Type: Journal Article) |
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