Impact of metabolic syndrome on tissue characteristics of angiographically mild to moderate coronary lesions integrated backscatter intravascular ultrasound study.

Abstract

OBJECTIVES:

We assessed the impact of metabolic syndrome (MetS) on the tissue characteristics of coronary plaques using integrated backscatter intravascular ultrasound (IB-IVUS).

BACKGROUND:

Metabolic syndrome is associated with the increasing risk of cardiovascular disease.

METHODS:

We identified MetS by the definition of the National Cholesterol Education Program in Adult Treatment Panel III criterion. Non-target coronary lesions with mild to moderate stenosis were measured by conventional and IB-IVUS parameters using 40-MHz (motorized pullback 0.5 mm/s) intravascular catheter. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for 10 mm length in each plaque. The 3-dimensional analyses were performed using commercially available software.

RESULTS:

The prevalence of MetS was 61 patients (50%) with 73 lesions (49%) among 122 patients with 148 lesions. Patients with MetS showed a significant increase in percentage lipid area (38 +/- 19% vs. 30 +/- 19%, p = 0.02) and percentage lipid volume (39 +/- 17% vs. 33 +/- 17%, p = 0.03), and they also showed a significant decrease in percentage of fibrous volume (57 +/- 14% vs. 61 +/- 13%, p = 0.03). Multivariate regression analysis after adjustment for potentially confounding risk factors showed that MetS remains correlated independently with the percentage of lipid volume (r = 0.223, p = 0.01). Logistic regression analysis after adjusting for confounding and non-MetS coronary risk factors showed that MetS (odds ratio 4.00, 95% confidence interval 1.33 to 12.0, p = 0.01) is proved to be an independent predictor of the lipid-rich plaque.

CONCLUSIONS:

Metabolic syndrome is associated with lipid-rich plaques, contributing to the increasing risk of plaque vulnerability.

• Authors: Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kosuke Arai, Kiminobu Yokoi, Hirohiko Ando, Hideki Ishii, Hideo Izawa, Toyoaki Murohara
• Journal: Journal of the American College of Cardiology (J Am Coll Cardiol) Vol. 49 Issue 11 Pg. 1149-56 (Mar 20 2007) ISSN: 1558-3597 [Electronic] United States
• PMID: 17367657 (Publication Type: Comparative Study, Journal Article)

Topics

• Age Factors
• Aged
• Angina, Unstable (diagnostic imaging, epidemiology)
• Chi-Square Distribution
• Coronary Angiography
• Coronary Stenosis (diagnostic imaging, epidemiology)
• Female
• Humans
• Immunohistochemistry
• Logistic Models
• Male
• Metabolic Syndrome (diagnosis, epidemiology)
• Middle Aged
• Multivariate Analysis
• Prevalence
• Prospective Studies
• Risk Assessment
• Sensitivity and Specificity
• Severity of Illness Index
• Sex Factors
• Statistics, Nonparametric
• Ultrasonography, Interventional