Abstract | PURPOSE: METHODS: RESULTS: We observed that mICON selectively destroyed choroidal neovascularization in a dose-dependent manner (r = -0.93; EDB50B = 571.3 microg). Obliteration of the choroidal neovascular complex was more prominent at doses > 300 microg (p < 0.05). No systemic or local complications (including retinal tear/detachment, inflammation, infection, cataract, or glaucoma) were observed. Binding specificities of hICON (2.2 +/- 0.2) and mICON (3.4 +/- 0.4) were significantly higher than that of anti-von Willebrand antibody (0.1 +/- 0.01, p < 0.001). CONCLUSIONS:
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Authors | Tongalp H Tezel, Ewa Bodek, Kenan Sönmez, Sankar Kaliappan, Henry J Kaplan, Zhiwei Hu, Alan Garen |
Journal | Ocular immunology and inflammation
(Ocul Immunol Inflamm)
2007 Jan-Feb
Vol. 15
Issue 1
Pg. 3-10
ISSN: 0927-3948 [Print] England |
PMID | 17365800
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin Fc Fragments
- Immunotoxins
- Recombinant Fusion Proteins
- Factor VII
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Topics |
- Animals
- Choroidal Neovascularization
(drug therapy, etiology, pathology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Factor VII
(immunology)
- Immunoglobulin Fc Fragments
- Immunotherapy
(methods)
- Immunotoxins
(therapeutic use)
- Injections
- Laser Coagulation
- Microscopy, Confocal
- Recombinant Fusion Proteins
(therapeutic use)
- Swine
- Swine, Miniature
- Treatment Outcome
- Vitreous Body
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