HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of the association of dual-site dynamic atrial overdrive and atenolol in preventing recurrent atrial fibrillation.

AbstractOBJECTIVE:
Evaluate the effects of optimized atrial stimulation--OAS (dual-site atrial pacing, heart rate above the intrinsic rate, and specific functional algorithm), and the use of atenolol in preventing recurrent atrial fibrillation (AF). Primary endpoint: to quantify the rate of AF episodes. Secondary endpoints: assessment of quality of life, specific cardiovascular symptoms, rate of hospital admissions, rate of electrical and pharmacological cardioversions, and adverse cardiac events.
METHODS:
Twenty-five patients with recurrent episodes of paroxysmal AF and sinus node disease had dual-site atrial and ventricular pacemakers implanted, and were started on atenolol, 100 mg/day. Next, they were randomized to two groups: GROUP I: first three months with OAS and the specific pacing algorithm (DAO) turned on, and three more months with the algorithm off. GROUP II: the inverse sequence to GROUP I. The pacing mode chosen was DDDR, and after three months patients underwent clinical and electronic evaluations of the stimulation system by: automatic mode switch (AMS), 24-hour Holter monitoring, Doppler echocardiogram, and SF-36 questionnaire. Following, a crossover comparison took place, and a new assessment was performed six months later.
RESULTS:
When compared to the group with the algorithm turned off, OAS patients had lower rates of: AF/week (p < 0.001); AMS activations (p < 0.01); hospitalizations (p < 0.001); cardioversions (p < 0.001), and higher scores on the physical and mental components of quality of life.
CONCLUSION:
The hybrid therapy adopted, OAS associated with the use of atenolol, reduced the rate of recurrent AF and improved the clinical-functional status of patients with symptomatic bradyarrhythmias.
AuthorsAntonio da Silva Menezes Jr, Martino Martinelli Filho, Carlos Cléber dos Santos Menezes, Roberto Costa, José Antônio Franchini Ramires
JournalArquivos brasileiros de cardiologia (Arq Bras Cardiol) Vol. 88 Issue 1 Pg. 1-7 (Jan 2007) ISSN: 1678-4170 [Electronic] Brazil
PMID17364111 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Arrhythmia Agents
  • Atenolol
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Anti-Arrhythmia Agents (therapeutic use)
  • Atenolol (therapeutic use)
  • Atrial Fibrillation (prevention & control)
  • Cardiac Pacing, Artificial
  • Combined Modality Therapy
  • Cross-Over Studies
  • Electric Countershock
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life
  • Secondary Prevention
  • Sick Sinus Syndrome (therapy)
  • Single-Blind Method
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: