Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: Immunohistochemical studies done on a panel of malignant melanomas showed positive immunostaining with mAb 4C5 in all cases. mAb 4C5 inhibits B16 F10 cell invasion by binding to surface HSP90 because it is not internalized. mAb 4C5 significantly inhibits melanoma metastasis in C57BL/6 mice inoculated with B16 F10 cells. CONCLUSIONS:
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Authors | Dimitris Stellas, Andreas Karameris, Evangelia Patsavoudi |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 13
Issue 6
Pg. 1831-8
(Mar 15 2007)
ISSN: 1078-0432 [Print] United States |
PMID | 17363539
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 4C5 monoclonal antibody
- Antibodies, Monoclonal
- Antigens
- HSP90 Heat-Shock Proteins
- antigen 4C5
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Topics |
- Animals
- Antibodies, Monoclonal
(immunology, pharmacology, therapeutic use)
- Antigens
(immunology, metabolism)
- Female
- HSP90 Heat-Shock Proteins
(metabolism)
- Humans
- Immunohistochemistry
- Immunotherapy
- Lung Neoplasms
(secondary, therapy)
- Melanoma
(metabolism, mortality, pathology, therapy)
- Mice
- Mice, Inbred C57BL
- Neoplasm Invasiveness
- Neoplasm Transplantation
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