Left ventricular myocardial performance index in closely-related relatives of patients with dilated cardiomyopathy.

Abstract

In this study, the left ventricular dimensions, systolic function, and left ventricular myocardial performance index in the first-degree relatives of the children with dilated cardiomyopathy (n=19), 30.0+/-17.6 years to normal age- and sex-matched controls (n=25), 27.4+/-17.7 years. The percentage ratio of the measured left ventricular end-diastolic dimension to the predicted left ventricular end-diastolic dimension (109+/-9.6 vs 105+/-11.8), left ventricular shortening fraction (34.5+/-6.6 vs 37.2+/-7%), and left ventricular ejection fraction (63.2+/-9.2 vs 66.5+/-8.1%) were not significantly different in the first-degree relatives and controls, respectively. However, the left ventricular myocardial performance index was significantly greater in the first-degree relatives than in controls (0.40+/-0.11 vs 0.31+/-0.03, p=0.01). In conclusion, the left ventricular myocardial performance index may be useful in early detect familial dilated cardiomyopathy in asymptomatic first-degree relatives of children with dilated cardiomyopathy.

• Authors: Anant Khositseth, Prapat Ausayapao
• Journal: International journal of cardiology (Int J Cardiol) Vol. 124 Issue 3 Pg. 375-7 (Mar 14 2008) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 17363090 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Cardiomyopathy, Dilated (diagnostic imaging, genetics, physiopathology)
• Echocardiography
• Family
• Female
• Genetic Predisposition to Disease
• Humans
• Male
• Ventricular Function, Left (physiology)