Abstract | BACKGROUND: Early detection of an acute rejection episode is an important problem in monitoring transplant patients. Erythropoietin (EPO) production is diminished in patients suffering from chronic renal insufficiency or acute rejection. Therefore, a decrease of reticulocyte counts and of young reticulocytes might indicate the emergence of an acute rejection episode. This pilot study examined the value of reticulocyte parameters as indicators of acute rejection episodes. PATIENTS AND METHODS: RESULTS: Acute rejection episodes were not accompanied by significantly altered reticulocyte parameters. During the first weeks, the reticulocyte count or the immature fraction, respectively, did not differ between patients with delayed versus immediate onset of renal function: reticulocyte count 1.70 +/- 1.06% vs 1.58 +/- 1.10% and ratio of immature (high fluorescent) reticulocytes 22.8 +/- 7.9% vs 17.6 +/- 9.4%). CONCLUSION: Reticulocyte counts and determination of the immature reticulocyte fraction were not significantly altered by an acute rejection episode. Various influences modulate the release of EPO and reaction of erythropoiesis upon an EPO stimulus.
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Authors | A Weimann, S Lun, C Müller, J Pratschke, P Reinke, A Lun |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 39
Issue 2
Pg. 514-7
(Mar 2007)
ISSN: 0041-1345 [Print] United States |
PMID | 17362771
(Publication Type: Journal Article)
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Chemical References |
- Erythropoietin
- Urea
- Creatinine
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Topics |
- Adult
- Aged
- Creatinine
(blood)
- Erythropoietin
(blood)
- Female
- Graft Rejection
(blood, diagnosis)
- Humans
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Reticulocyte Count
- Urea
(blood)
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