Abstract | PURPOSE: MATERIALS AND METHODS: Male Wistar rats were pretreated with DETC (100 mg/kg IV) 10 minutes before hepatic ischemia, which was followed by 2 hours reperfusion, or 10 minutes prior to the reperfusion. Blood samples were obtained at the end of the reperfusion period to determine the biochemical markers of liver injury. Results were compared using the one-way analysis of variance (ANOVA), followed by the Bonferroni posttest, and presented as mean values +/- SEM. RESULTS: CONCLUSION: DETC, administered just before the reperfusion period, resulted in a significant decrease in the I/R injury to the liver, an observation that may have therapeutic implications.
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Authors | R Maio, B Sepodes, N Figueiredo, R Pinto, M McDonald, C Thiermermann, P Costa, H Mota-Filipe |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 39
Issue 2
Pg. 365-8
(Mar 2007)
ISSN: 0041-1345 [Print] United States |
PMID | 17362731
(Publication Type: Journal Article)
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Chemical References |
- Chelating Agents
- Malondialdehyde
- Ditiocarb
- L-Lactate Dehydrogenase
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Aspartate Aminotransferases
(blood)
- Chelating Agents
- Ditiocarb
(pharmacology)
- Kinetics
- L-Lactate Dehydrogenase
(blood)
- Liver
(drug effects, injuries)
- Liver Function Tests
- Male
- Malondialdehyde
(metabolism)
- Rats
- Rats, Wistar
- Reperfusion Injury
(prevention & control)
- gamma-Glutamyltransferase
(blood)
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