Abstract |
Carboplatin is widely used in pediatric oncology to treat different tumors. Aim of the present study was to assess the potential of sector field inductively coupled plasma mass spectrometry (SF-ICPMS) in evaluating the area under the plasma platinum concentration vs time curve in pediatric patients presenting solid tumors and treated with carboplatin 349-1000 mg m-2. Seventeen patients were enrolled and 23 courses of chemotherapy were evaluated. Plasma was ultrafiltered and free carboplatin was measured in ultrafiltrates as platinum by SF-ICP-MS. Comparison was made between different equations to obtain a target AUC. Limits of detection and of quantification, intra- and inter-day repeatability of the measurements, recovery of the 'free- carboplatin' confirmed SF-ICP-MS as a reliable technique in the quantification of serum platinum in anticancer carboplatin-based therapies.
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Authors | Anna Clerico, Carlo Cappelli, Giuseppina Ragni, Sergio Caroli, Maria Antonietta De Ioris, Alessia Sordi, Francesco Petrucci, Beatrice Bocca, Alessandro Alimonti |
Journal | Annali dell'Istituto superiore di sanita
(Ann Ist Super Sanita)
Vol. 42
Issue 4
Pg. 461-8
( 2006)
ISSN: 0021-2571 [Print] Italy |
PMID | 17361071
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Platinum
- Carboplatin
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Topics |
- Adolescent
- Adult
- Antineoplastic Agents
(pharmacokinetics, therapeutic use)
- Area Under Curve
- Brain Neoplasms
(drug therapy)
- Carboplatin
(pharmacokinetics, therapeutic use)
- Child
- Child, Preschool
- Female
- Humans
- Male
- Mass Spectrometry
- Myosarcoma
(drug therapy)
- Neoplasms
(drug therapy)
- Neoplasms, Muscle Tissue
(drug therapy)
- Platinum
(analysis)
- Rhabdomyosarcoma
(drug therapy)
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