[Therapeutic effect of Hongbeiyegen on alcohol-induced rat hepatic fibrosis].

Abstract

OBJECTIVE:

To observe the therapeutic effect of Hongbeiyegen [the root of Alchornea trewioides(Benth.) Muell.-Arg.] on alcohol-induced liver fibrosis (AF) in rats and explore its mechanism.

METHODS:

In rats with AF, the serum levels of transforming growth factor beta1 (TGFbeta1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were detected along with examination of the changes in serum hyaluronic acid (HA), laminin (LN), procolagen type III (PC III), collagen type IV (C IV), glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminase (AST) levels.

RESULTS:

Compared with the control group, Hongbeiyegen could significantly reduce the levels of TGFbeta1, TIMP-1, HA, LN, PC III, CIV, ALT and AST in rats with AF.

CONCLUSION:

Hongbeiyegen can relieve and ameliorate liver fibrosis possibly by inhibiting the expression of TGFbeta1 and TIMP-1.

• Authors: Xiao-Yan Lü, Qiang Liu, Yu-Yao Chen, Yu-Hong Song, Zhi-Ping Lü
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 27 Issue 2 Pg. 153-5 (Feb 2007) ISSN: 1673-4254 [Print] China
• PMID: 17355923 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type III
• Collagen Type IV
• Drugs, Chinese Herbal
• Laminin
• Tissue Inhibitor of Metalloproteinase-1
• Transforming Growth Factor beta1
• hongbeiyegen
• Ethanol
• Hyaluronic Acid
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Collagen Type III (blood)
• Collagen Type IV (blood)
• Drugs, Chinese Herbal (therapeutic use)
• Ethanol
• Euphorbiaceae (chemistry)
• Female
• Hyaluronic Acid (blood)
• Laminin (blood)
• Liver Cirrhosis, Experimental (blood, chemically induced, drug therapy)
• Male
• Phytotherapy
• Plant Roots (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Tissue Inhibitor of Metalloproteinase-1 (blood)
• Transforming Growth Factor beta1 (blood)