Abstract |
A novel two-step synthesis of substituted 2-formylpyrroles is described. Aldol adducts of ketones and 4-formyloxazole undergo a dehydration/ oxazole hydrolysis/cyclization cascade on sequential treatment with MsCl/Et3N and aqueous NaOH to yield 5-substituted and 4,5-disubstituted 2-formylpyrroles. The methodology was extended to an N-benzyl thiazolium salt.
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Authors | Jonathan T Reeves, Jinhua J Song, Zhulin Tan, Heewon Lee, Nathan K Yee, Chris H Senanayake |
Journal | Organic letters
(Org Lett)
Vol. 9
Issue 10
Pg. 1875-8
(May 10 2007)
ISSN: 1523-7060 [Print] United States |
PMID | 17355146
(Publication Type: Journal Article)
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Chemical References |
- 4-formyloxazole
- Formates
- Ketones
- Oxazoles
- Pyrroles
- formic acid
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Topics |
- Formates
(chemistry)
- Hydroxylation
- Ketones
(chemistry)
- Molecular Structure
- Oxazoles
(chemistry)
- Pyrroles
(chemical synthesis, chemistry)
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