Abstract | BACKGROUND AND STUDY AIMS: PATIENTS AND METHODS: A total of 67 patients (37 men, 30 women; mean age +/- standard deviation [SD] 60 +/- 17 years) with initially successful Histoacryl obliteration of bleeding gastric varices were included in the study and randomly divided into two groups: a "combined" group of patients who had adjuvant injection of hypertonic glucose solutions in cases of residual gastric varices (F1 or less) and a "control" group of patients who did not receive such therapy. End points were either variceal recurrence/progression (F2 or more) requiring Histoacryl reinjection or rebleeding. RESULTS: Residual small varices were found in 56% of patients in the combined group and in 60% of patients in the control group. Adjuvant therapy was only performed in the combined group. During the follow-up period (mean duration +/- SD 37.9 +/- 18.5 months, range 19-56 months), two patients in the combined group showed gastric variceal progression, compared with nine patients showing progression in the control group, with two cases of rebleeding, both occurring in the control group. Two years after the first Histoacryl injection, the cumulative proportion of patients who did not have gastric variceal progression was significantly higher in the combined group than it was in the control group (92.8% vs. 71.4%, P = 0.029). There was no significant difference between the two groups with respect to their survival curves (P = 0.12). No marked immediate or delayed symptoms or complications were observed in the patients given hypertonic glucose injections. CONCLUSIONS:
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Authors | M-J Kuo, H-Z Yeh, G-H Chen, S-K Poon, S-S Yang, H-C Lien, C-S Chang |
Journal | Endoscopy
(Endoscopy)
Vol. 39
Issue 6
Pg. 487-91
(Jun 2007)
ISSN: 1438-8812 [Electronic] Germany |
PMID | 17354182
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucose Solution, Hypertonic
- Sclerosing Solutions
- Tissue Adhesives
- Enbucrilate
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Topics |
- Adult
- Aged
- Disease Progression
- Drug Therapy, Combination
- Enbucrilate
(administration & dosage)
- Esophageal and Gastric Varices
(complications, drug therapy, therapy)
- Female
- Gastrointestinal Hemorrhage
(etiology, therapy)
- Gastroscopy
- Glucose Solution, Hypertonic
(administration & dosage)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Sclerosing Solutions
(administration & dosage)
- Secondary Prevention
- Tissue Adhesives
(administration & dosage)
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