[A case of advanced clear cell carcinoma of the endometrium that responded remarkably to neoadjuvant chemotherapy of combination carboplatin plus weekly paclitaxel].

Abstract

Clear cell carcinoma of the endometrium is a very rare and highly malignant neoplasm that accounts for less than 5% of endometrial carcinoma. Survival of patients in the advanced stage is poor, and the treatment of choice is not clear. We report the case of a 62-year-old woman who had Stage IVb advanced clear cell carcinoma of the endometrium with multiple lung metastases. The lesions were considered surgically incurable, so she was placed on neoadjuvant chemotherapy of combination carboplatin (CBDCA) (AUC 5, day 1) plus weekly paclitaxel (PTX) (70 mg/m(2), day 1, 8, 15). After 3 courses of chemotherapy, the uterine tumor was obviously reduced, and lung metastases had disappeared. Therefore, she underwent the operation. The current case suggests that combination CBDCA plus weekly PTX is effective against advanced clear cell carcinoma of the endometrium.

• Authors: Masashi Takami, Yoshiaki Ohta, Yasuo Nakayama, Hiroshi Fukai, Hiroshi Matsumoto, Toshiro Takimoto, Hideki Sakamoto, Tatsuo Yamamoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 3 Pg. 457-60 (Mar 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17353643 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Carboplatin
• Paclitaxel

Topics

• Adenocarcinoma, Clear Cell (drug therapy, secondary, surgery)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (administration & dosage)
• Combined Modality Therapy
• Drug Administration Schedule
• Endometrial Neoplasms (drug therapy, pathology, surgery)
• Female
• Humans
• Hysterotomy
• Lung Neoplasms (drug therapy, secondary)
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Paclitaxel (administration & dosage)
• Remission Induction