[A case of carcinomatous cardiac tamponade due to breast cancer treated with OK-432 and mitomycin C].

Abstract

The patient was a 40-year-old woman who was admitted to our hospital because of severe cough and dyspnea due to multiple lung metastases from breast cancer, who had undergone Auchincloss operation for right breast cancer about five years earlier. While systemic chemotherapy (CAF) was started after admission,she presented with cardiac tamponade. A cardiac echogram revealed marked retention of pericardial effusion. Pericardiocentesis was carried out, and the cytology of the effusion showed class V, resulting in the diagnosis of carcinomatous cardiac tamponade due to breast cancer. She was treated with intrapericardial chemotherapy using OK-432 and mitomycin C (MMC), and has not suffered from pericardial effusion after the intrapericardial chemotherapy. Intrapericardial chemotherapy using OK-432 and MMC may be very useful for malignant pericardial effusion.

• Authors: Shigeki Wakiyama, Ken Shirabe, Takashi Nagaie
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 3 Pg. 439-41 (Mar 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17353639 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Picibanil
• Mitomycin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, pathology, surgery)
• Carcinoma, Ductal, Breast (drug therapy, secondary)
• Cardiac Tamponade (drug therapy, etiology)
• Drug Administration Schedule
• Female
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Mitomycin (administration & dosage)
• Pericardial Effusion (drug therapy, etiology, therapy)
• Pericardiocentesis
• Picibanil (administration & dosage)
• Quality of Life