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Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.

Abstract
Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.
AuthorsAlice S Chen-Plotkin, Keith A Vossel, Martin A Samuels, Ming Hui Chen
JournalNeurology (Neurology) Vol. 68 Issue 11 Pg. 859-61 (Mar 13 2007) ISSN: 1526-632X [Electronic] United States
PMID17353475 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dimethyl Sulfoxide
Topics
  • Brain Injuries (chemically induced, diagnosis, etiology)
  • Dimethyl Sulfoxide (adverse effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction (chemically induced, diagnosis, etiology)
  • Stem Cell Transplantation (adverse effects)
  • Stroke (chemically induced, diagnosis, etiology)

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