Abstract | BACKGROUND: METHODS: The effectiveness of three daily doses of artesunate plus amodiaquine combination given unsupervised (n = 32), compared with the efficacy when given under full supervision (n = 29) to children with falciparum malaria were assessed in an unrandomized study. RESULTS: 61 patients analysed revealed a PCR-corrected day-28 cure rate of 86 % (25 of 29 patients; CI 69-95 %) in the supervised group and 63 % (20 of 32 patients; CI 45-77 %) in the unsupervised group. The difference in outcome between both groups was statistically significant (p = 0.04). No severe adverse events were reported. CONCLUSION: The effectiveness of this short course regimen in young children with falciparum malaria could be augmented by increased adherence and improved formulation.
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Authors | Sunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Ospina Salazar, Bertrand Lell, Jürgen F J Kun, Peter G Kremsner, Martin P Grobusch |
Journal | Malaria journal
(Malar J)
Vol. 6
Pg. 29
(Mar 12 2007)
ISSN: 1475-2875 [Electronic] England |
PMID | 17352806
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Artemisinins
- Sesquiterpenes
- Amodiaquine
- Artesunate
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Topics |
- Amodiaquine
(administration & dosage, adverse effects, therapeutic use)
- Animals
- Antimalarials
(administration & dosage, adverse effects, therapeutic use)
- Artemisinins
(administration & dosage, adverse effects, therapeutic use)
- Artesunate
- Child, Preschool
- Drug Therapy, Combination
- Gabon
- Humans
- Infant
- Malaria, Falciparum
(drug therapy, parasitology)
- Plasmodium falciparum
(drug effects)
- Sesquiterpenes
(administration & dosage, adverse effects, therapeutic use)
- Treatment Outcome
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