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Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children.

AbstractBACKGROUND:
Artesunate-amodiaquine combination for the treatment of childhood malaria is one of the artemisinin combination therapies (ACTs) recommended by National authorities in many African countries today. Effectiveness data on this combination in young children is scarce.
METHODS:
The effectiveness of three daily doses of artesunate plus amodiaquine combination given unsupervised (n = 32), compared with the efficacy when given under full supervision (n = 29) to children with falciparum malaria were assessed in an unrandomized study.
RESULTS:
61 patients analysed revealed a PCR-corrected day-28 cure rate of 86 % (25 of 29 patients; CI 69-95 %) in the supervised group and 63 % (20 of 32 patients; CI 45-77 %) in the unsupervised group. The difference in outcome between both groups was statistically significant (p = 0.04). No severe adverse events were reported.
CONCLUSION:
The effectiveness of this short course regimen in young children with falciparum malaria could be augmented by increased adherence and improved formulation.
AuthorsSunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Ospina Salazar, Bertrand Lell, Jürgen F J Kun, Peter G Kremsner, Martin P Grobusch
JournalMalaria journal (Malar J) Vol. 6 Pg. 29 (Mar 12 2007) ISSN: 1475-2875 [Electronic] England
PMID17352806 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimalarials
  • Artemisinins
  • Sesquiterpenes
  • Amodiaquine
  • Artesunate
Topics
  • Amodiaquine (administration & dosage, adverse effects, therapeutic use)
  • Animals
  • Antimalarials (administration & dosage, adverse effects, therapeutic use)
  • Artemisinins (administration & dosage, adverse effects, therapeutic use)
  • Artesunate
  • Child, Preschool
  • Drug Therapy, Combination
  • Gabon
  • Humans
  • Infant
  • Malaria, Falciparum (drug therapy, parasitology)
  • Plasmodium falciparum (drug effects)
  • Sesquiterpenes (administration & dosage, adverse effects, therapeutic use)
  • Treatment Outcome

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