The use of Hyalomatrix PA in the treatment of deep partial-thickness burns.

Abstract

Since 2001, Hyalomatrix PA (Fidia Advanced Biopolymers, Abano Terme, Italy) has been used in our center on pediatric burned patients as a temporary dermal substitute to cover deep partial-thickness burns after dermabrasion. This "bridge" treatment was adopted to remove necrotic debris (dermabrasion) and to stimulate regeneration in a humid and protected environment (Hyalomatrix PA). We present results obtained with this approach. On the third to fifth day after admission, dermabrasion was practiced on deep burned areas, which were covered with Hyalomatrix PA. Change of dressings was performed every 7 days. On day 21, those areas still without signs of recovery were removed with classic escharectomy and covered with thin skin grafts. We treated 300 patients. Sixty-one percent needed only one dermabrasion treatment, 22.3% (67 patients) more than one, and 16.7% (50 patients) the classic escharectomy. A total of 83% of patients healed within 21 days. Our study suggests that the combination of dermabrasion with a temporary dermal substitute could be a good and feasible approach for treatment of deep partial-thickness burns. Prospective randomized studies are now necessary to compare our protocol with the gold standard treatment of topical dressings.

• Authors: Gianpiero Gravante, Daniela Delogu, Nicola Giordan, Giuseppina Morano, Antonio Montone, Gaetano Esposito
• Journal: Journal of burn care & research : official publication of the American Burn Association (J Burn Care Res) 2007 Mar-Apr Vol. 28 Issue 2 Pg. 269-74 ISSN: 1559-047X [Print] England
• PMID: 17351444 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Anti-Bacterial Agents
• Disinfectants

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Bandages
• Burns (epidemiology, therapy)
• Child
• Child, Preschool
• Cicatrix, Hypertrophic (drug therapy, epidemiology)
• Dermabrasion
• Disinfectants (therapeutic use)
• Female
• Humans
• Infant
• Injections, Intralesional
• Male
• Skin Transplantation
• Skin, Artificial
• Treatment Outcome
• Wound Infection (epidemiology, therapy)