Src kinase signaling in leukaemia.

Abstract

Role of Src kinases in acute lymphoblastic leukaemia has been recently demonstrated in leukaemia mouse model. Retained activation of Src kinases by the BCR-ABL oncoprotein in leukaemic cells following inhibition of BCR-ABL kinase activity by imatinib indicates that Src activation by BCR-ABL is independent of BCR-ABL kinase activity and provides an explanation for reduced effectiveness of the BCR-ABL kinase activity inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukaemia. Simultaneous inhibition of kinase activity of both BCR-ABL and Src kinases results in long-term survival of mice with acute lymphoblastic leukaemia. Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease.

• Authors: Shaoguang Li
• Journal: The international journal of biochemistry & cell biology (Int J Biochem Cell Biol) Vol. 39 Issue 7-8 Pg. 1483-8 ( 2007) ISSN: 1357-2725 [Print] Netherlands
• PMID: 17350876 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Pyrimidines
• Imatinib Mesylate
• src-Family Kinases

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Benzamides
• Cell Survival (drug effects)
• Enzyme Activation
• Gene Expression Regulation, Leukemic
• Genes, abl (physiology)
• Humans
• Imatinib Mesylate
• Mice
• Neoplastic Stem Cells (cytology)
• Piperazines (pharmacology, therapeutic use)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (enzymology)
• Pyrimidines (pharmacology, therapeutic use)
• Signal Transduction
• src-Family Kinases (antagonists & inhibitors, physiology)