Raxofelast, (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid: a new antioxidant to modulate the inflammatory response during ischemia-reperfusion injury and impaired wound healing.

Abstract	Raxofelast, also named IRFI 016 or (+/-)5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid, belongs to a family of novel molecules designed with the aim to maximize antioxidant potency of phenols related to Vitamin E (alpha-tocopherol). This review will focus on the antioxidant and radical scavenging activity of this new promising compound.
Authors	A Bitto, L Minutoli, F Squadrito, F Polito, D Altavilla
Journal	Mini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 7 Issue 3 Pg. 339-43 (Mar 2007) ISSN: 1389-5575 [Print] Netherlands
PMID	17346222 (Publication Type: Journal Article, Review)
Chemical References	Antioxidants Benzofurans Vitamin E Raxofelast
Topics	Animals Antioxidants (chemistry, pharmacokinetics, therapeutic use) Benzofurans (chemistry, pharmacokinetics, therapeutic use) Biological Availability Humans Inflammation (drug therapy, etiology) Molecular Structure Reperfusion Injury (complications, drug therapy, physiopathology) Vitamin E (analogs & derivatives, chemistry, pharmacokinetics, therapeutic use) Wound Healing (drug effects)

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