Ovarian cancer activity of cyclic amine and thiaether metal complexes.

Abstract

A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.

• Authors: Doug A Medvetz, Kimberly D Stakleff, Tara Schreiber, Paul D Custer, Khadijah Hindi, Matthew J Panzner, Denise D Blanco, Michael J Taschner, Claire A Tessier, Wiley J Youngs
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 50 Issue 7 Pg. 1703-6 (Apr 05 2007) ISSN: 0022-2623 [Print] United States
• PMID: 17343369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• Organometallic Compounds
• trichloro(1-aza-4,7-dithiacyclononane)rhodium(III)
• Copper
• Ruthenium
• Rhodium

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line
• Cell Line, Tumor
• Copper
• Drug Screening Assays, Antitumor
• Female
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Ovarian Neoplasms
• Rats
• Rats, Inbred F344
• Rhodium
• Ruthenium
• Structure-Activity Relationship