Platelet glycoprotein VI: a novel marker for acute coronary syndrome.

Abstract

The platelet collagen receptor glycoprotein (GP) VI is critical for the formation of arterial thrombosis. GPVI platelet surface expression was examined in patients with stable angina and in patients with acute coronary syndrome (ACS). Surface expression of platelet activation markers such as P-selectin, GPIbalpha, and platelet GPVI was determined by flow cytometry. Patients with ACS showed a significantly enhanced GPVI expression compared with patients with stable angina and healthy controls. The expression of GPVI correlated well with CD62P. Elevated platelet GPVI expression was associated with ACS independent of markers of myocardial necrosis such as troponin and creatine kinase. In ACS, platelet surface GPVI expression was already elevated several hours before troponin and creatine kinase indicated myocardial injury. We conclude that the determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischemia is evident.

• Authors: Boris Bigalke, Harald Langer, Tobias Geisler, Stephan Lindemann, Meinrad Gawaz
• Journal: Seminars in thrombosis and hemostasis (Semin Thromb Hemost) Vol. 33 Issue 2 Pg. 179-84 (Mar 2007) ISSN: 0094-6176 [Print] United States
• PMID: 17340467 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Platelet Membrane Glycoproteins
• platelet membrane glycoprotein VI

Topics

• Biomarkers (blood)
• Disease Susceptibility (diagnosis)
• Humans
• Myocardial Ischemia (blood, diagnosis)
• Platelet Membrane Glycoproteins (analysis)
• Thrombosis (blood, etiology)