Mohs micrographic surgery in the treatment of rare aggressive cutaneous tumors: the Geisinger experience.

Mohs micrographic surgery (MMS) offers high cure rates and maximum tissue preservation in the treatment of more common cutaneous malignancies, but its effectiveness in rare aggressive tumors is poorly defined.
Evaluate the effectiveness of MMS in the treatment of six rare aggressive cutaneous malignancies as seen by Mohs surgeons working at a referral center.
Retrospective chart review of 26,000 cases treated with MMS at the Geisinger Medical Center Department of Dermatology during a 16-year period with the following diagnoses: poorly differentiated squamous cell carcinoma (PDSCC), dermatofibrosarcoma protuberans (DFSP), microcystic adnexal carcinoma (MAC), extramammary Paget's disease (EMPD), Merkel cell carcinoma (MCC), and sebaceous carcinoma (SEB CA). Patient demographic data, tumor measurements, treatment characteristics, and marginal recurrence rates were compiled and evaluated.
The mean numbers of cases identified per year for each tumor type were as follows: PDSCC, 6.19; DFSP, 2.44; MAC, 1.63; and EMPD, 0.63. For PDSCC, 85 cases were available for follow-up with a local recurrence rate of 6% at a mean follow-up time of 45 months. For DFSP, there were 35 cases with no local recurrence at a mean follow-up of 39 months. For MAC, there were 25 cases with a local recurrence rate of 12% at a mean follow-up of 39 months. For EMPD, there were 10 cases with no local recurrences at a mean follow-up of 34 months.
Collectively, our data on PDSCC, DFSP, MAC, and EMPD, combined with other studies in the literature, show that MMS is the most effective therapy for these rare aggressive cutaneous malignancies.
AuthorsChadwick John Thomas, G Craig Wood, Victor J Marks
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 33 Issue 3 Pg. 333-9 (Mar 2007) ISSN: 1076-0512 [Print] United States
PMID17338692 (Publication Type: Journal Article)
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Merkel Cell (surgery)
  • Carcinoma, Squamous Cell (surgery)
  • Child
  • Child, Preschool
  • Dermatofibrosarcoma (surgery)
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Mohs Surgery
  • Neoplasm Recurrence, Local (epidemiology)
  • Paget's Disease, Mammary (surgery)
  • Retrospective Studies
  • Skin Neoplasms (surgery)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: