Abstract |
Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphism and high mitotic index (more than 4 mitoses within 4 visual fields, at high magnification) were used as malignancy criteria:. Tumor histological pattern of "hemangiopericytic" variety could be reliably identified thanks to immunohistochemical procedure.
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Authors | E E Leenman, S D Popov, I V Dvorakovskaia, A I Arsen'ev, K M Pozharisskiĭ |
Journal | Voprosy onkologii
(Vopr Onkol)
Vol. 52
Issue 6
Pg. 624-32
( 2006)
ISSN: 0507-3758 [Print] Russia (Federation) |
PMID | 17338238
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- 12E7 Antigen
- Actins
- Antigens, CD
- Antigens, CD34
- Biomarkers, Tumor
- CD99 protein, human
- Cell Adhesion Molecules
- Desmin
- S100 Proteins
- Vimentin
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Topics |
- 12E7 Antigen
- Actins
(analysis)
- Aged
- Antigens, CD
(analysis)
- Antigens, CD34
(analysis)
- Biomarkers, Tumor
(analysis)
- Cell Adhesion Molecules
(analysis)
- Child
- Desmin
(analysis)
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mitotic Index
- Necrosis
- Neoplasms, Fibrous Tissue
(chemistry, pathology)
- Polymorphism, Genetic
- S100 Proteins
(analysis)
- Vimentin
(analysis)
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