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Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp.

Abstract
A new steroid with an uncommon 21-oic acid methyl ester moiety designated methyl spongoate (1) which exhibited potent cytotoxicity against BEL-7402 tumor cells in vitro has been isolated from the Sanya soft coral Spongodes sp. Its structure was determined by detailed interpretation of spectroscopic data and by comparison with related compounds.
AuthorsXiao-Hong Yan, Li-Ping Lin, Jian Ding, Yue-Wei Guo
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 17 Issue 9 Pg. 2661-3 (May 01 2007) ISSN: 0960-894X [Print] England
PMID17337188 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Esters
  • Steroids
  • methyl spongoate
Topics
  • Animals
  • Anthozoa
  • Antineoplastic Agents (chemistry, pharmacology)
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical (methods)
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Esters (chemistry)
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Molecular Conformation
  • Spectrophotometry
  • Steroids (chemistry, pharmacology)

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