HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.

Abstract
Marijuana abuse continues to plague society and the lack of effective treatments warrants concern. Catalytic antibodies capable of oxidatively degrading the major psychoactive component of marijuana, Delta9-tetrahydrocannabinol (Delta9-THC), are presented. The antibodies generate reactive oxygen species from singlet oxygen (1O2*), using riboflavin (vitamin B2) and visible light as the 1O2* source. Cannabitriol was identified as the major degradation product of this reaction, demonstrating the ability of an antibody to catalyze a complex chemical transformation with therapeutic implications for treating marijuana abuse.
AuthorsAndrew P Brogan, Lisa M Eubanks, George F Koob, Tobin J Dickerson, Kim D Janda
JournalJournal of the American Chemical Society (J Am Chem Soc) Vol. 129 Issue 12 Pg. 3698-702 (Mar 28 2007) ISSN: 0002-7863 [Print] United States
PMID17335216 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • Dronabinol
Topics
  • Antibodies (chemistry)
  • Catalysis
  • Dronabinol (chemistry)
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Oxidation-Reduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: