Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.

Marijuana abuse continues to plague society and the lack of effective treatments warrants concern. Catalytic antibodies capable of oxidatively degrading the major psychoactive component of marijuana, Delta9-tetrahydrocannabinol (Delta9-THC), are presented. The antibodies generate reactive oxygen species from singlet oxygen (1O2*), using riboflavin (vitamin B2) and visible light as the 1O2* source. Cannabitriol was identified as the major degradation product of this reaction, demonstrating the ability of an antibody to catalyze a complex chemical transformation with therapeutic implications for treating marijuana abuse.
AuthorsAndrew P Brogan, Lisa M Eubanks, George F Koob, Tobin J Dickerson, Kim D Janda
JournalJournal of the American Chemical Society (J Am Chem Soc) Vol. 129 Issue 12 Pg. 3698-702 (Mar 28 2007) ISSN: 0002-7863 [Print] United States
PMID17335216 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • Dronabinol
  • Antibodies (chemistry)
  • Catalysis
  • Dronabinol (chemistry)
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Oxidation-Reduction

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