Abstract | OBJECTIVE: STUDY DESIGN: A double-blind, randomized, multicenter study was conducted on 231 women undergoing first-trimester legal abortion and fulfilling the criteria for bacterial vaginosis. The women were randomized to either metronidazole 500 mg three times daily for 10 days or placebo. Treatment was started at the outpatient visit the week before the operation. RESULTS: Among the 174 women who could be evaluated, pelvic inflammatory disease developed in 14 after the abortion. In the treatment group there were three infections (3.8%) compared with 11 (12.2%) in the placebo group (p less than 0.05). CONCLUSION: These data suggest that patients with bacterial vaginosis should be treated in conjunction with first-trimester abortion because treatment with metronidazole reduces the postoperative infection rate more than three times.
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Authors | P G Larsson, J J Platz-Christensen, H Thejls, U Forsum, C Påhlson |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 166
Issue 1 Pt 1
Pg. 100-3
(Jan 1992)
ISSN: 0002-9378 [Print] United States |
PMID | 1733176
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Abortion, Induced
(adverse effects)
- Chlamydia Infections
(complications)
- Chlamydia trachomatis
- Female
- Gonorrhea
(complications)
- Humans
- Metronidazole
(therapeutic use)
- Pelvic Inflammatory Disease
(etiology, prevention & control)
- Pregnancy
- Sweden
- Vaginosis, Bacterial
(complications)
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