| Abstract | This open-label prospective study evaluated the efficacy of letrozole (2.5 mg/day) combined with norethisterone acetate (2.5 mg/day) in the treatment of pain symptoms related to the presence of rectovaginal endometriosis. The treatment significantly and quickly decreased the intensity of symptoms, but pain recurred at 3-month follow-up; five women underwent surgery during the follow-up, and histologic examination of rectovaginal nodules revealed the presence of active endometriotic lesions. |
| Authors | Valentino Remorgida, Helena Luiza Abbamonte, Nicola Ragni, Ezio Fulcheri, Simone Ferrero
(Affiliation: Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Genoa, Italy.)
|
| Journal | Fertility and sterility
(Fertil Steril)
Vol. 88
Issue 3
Pg. 724-6
(Sep 2007)
ISSN: 1556-5653 United States |
| PMID | 17331508
(Publication Type: Clinical Trial, Journal Article)
|
| Chemical References |
- Aromatase Inhibitors
- Contraceptives, Oral, Synthetic
- Nitriles
- Triazoles
- letrozole
- norethindrone acetate
- Norethindrone
|
| Topics |
- Administration, Oral
- Aromatase Inhibitors
(administration & dosage, therapeutic use)
- Contraceptives, Oral, Synthetic
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Female
- Humans
- Nitriles
(administration & dosage, therapeutic use)
- Norethindrone
(analogs & derivatives)
- Prospective Studies
- Rectal Diseases
(drug therapy)
- Triazoles
(administration & dosage, therapeutic use)
- Vaginal Diseases
(drug therapy)
|
